ABSTRACT IWISH 2012 Julian King
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چکیده
The present paper reviews some paradigmatic applications of modeling and simulation in the context of exhaled breath analysis, which has emerged as a promising tool for collecting non-invasive and continuous information on the metabolic and physiological state of an individual. In particular, it is illustrated how real-time breath profiles of volatile organic compounds (as obtained, e.g., by PTR-(TOF)MS) can be used to extract in vivo estimates of endogenous quantities that are difficult to access by conventional analytical approaches based on blood, urine, or tissue. Typical examples include the determination of production and metabolism rates, as well as tracking the tissue accumulation of exogenously administered trace gases (e.g., volatile anesthetics).
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Author's response to reviews Title:A checklist designed to aid consistency and reproducibility of GRADE assessments: development and pilot validation Authors:
Nick Meader ([email protected]) Kristel King ([email protected]) Alexis Llewellyn ([email protected]) Gill Norman ([email protected]) Jennifer Brown ([email protected]) Mark Rodgers ([email protected]) Thirimon Moe-Byrne ([email protected]) Julian PT Higgins ([email protected]) Amanda Sowden ([email protected]) Gavin Stewart (gavin.stewa...
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تاریخ انتشار 2012